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Two-year research engineer position in single-molecule imaging applied to DNA repair, Rennes, France

Posted on 21 October 2024

Location: Rennes, France

Closing Date: 21 December 2024

Project title
Analysis of the dynamics of DNA repair proteins using single molecule tracking in living cells.

Job description
One research engineer position is available in the group of Sébastien Huet for a period of 2 years starting early 2025. The team belongs to the Institut de Génétique et du Développement de Rennes (http://igdr.univ-rennes1.fr/). It is currently composed of seven people with complementary expertise (molecular and cellular biology, biophysics, fluorescence imaging, mathematical modeling). The team is interested in the analysis of the early steps of the DNA repair mechanisms, focusing on the behavior of the two first responders PARP1 and OGG1 which detect single-strand breaks or 8-oxoguanine, respectively. Using advanced live-cell imaging approaches, the team investigates the target-search mechanisms used by these two factors to efficiently find their cognate lesions along the genome and characterizes their dynamic association with these lesions. The recruited engineer will be involved in the development of single-molecule imaging approaches to track individual fluorescently tagged PARP1 and OGG1 in living cells. These developments will be performed in close collaboration with the lab of Ignacio Izeddin from the Institut Langevin in Paris.

Qualifications
The applicant should hold a PhD in biophysics or cell biology. A proven experience in live-cell fluorescence microscopy is a prerequisite. Some knowledge in the DNA repair field will also be appreciated.

Contact
Applications should include a CV with a publication list, a motivation letter and contact details for two professional referees. They should be sent to Dr. Sébastien Huet (email: sebastien.huet@univ-rennes1.fr).

Recent publications
Zentout et al., PNAS, 2024, doi: 10.1073/pnas.2322689121.
Cabriel et al., Nature Phot., 2023, doi: 10.1038/s41566-023-01308-8.
D’Augustin et al., Nucleic Acids Res., 2023, doi: 10.1093/nar/gkad243.

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