PhD in Single-Molecule Localization Microscopy for Neuroscience

Synuclein diffusion analysis in neurons using event-based super-resolution microscopy

We are looking for a motivated candidate for a co-supervised PhD funded by the program LightInParis. It aims to study the mobility of the protein alpha-synuclein in neurons to understand the molecular mechanisms underlying its accumulation, associated with certain neurodegenerative pathologies. The description of these mechanisms will rely on the use of event-based microscopy. The PhD will be supervised by Christian Specht (DHNS, Inserm, Université Paris-Saclay, Le Kremlin-Bicêtre, France), and co-supervised by Ignacio Izeddin and Clément Cabriel (Institut Langevin, ESPCI Paris, Université PSL, CNRS, Paris, France).

Eligibility criteria: the application needs to respect the MSCA-COFUND mobility rule. In particular, the candidate must not have studied/worked in France more than 12 months during the last 36 derniers months (at the starting date of the contract).

Host institutes:
– DHNS (Inserm / Université Paris-Saclay), Le Kremlin-Bicêtre, France
– Institut Langevin (ESPCI Paris / PSL University / CNRS), Paris, France

More information about the offer:
https://lightinparis.eu/synuclein-diffusion-analysis-in-neurons-using-event-based-super-resolution-microscopy-seven
https://lightinparis.eu/wp-content/uploads/2025/01/COFUND_LightInParis_SPECHT.pdf

More information about our research activities:
https://www.institut-langevin.espci.fr/clement_cabriel?lang=en
https://www.institut-langevin.espci.fr/ignacio_izeddin?lang=en
https://dhns-inserm.fr/res_amyloidopathies/

How to apply: please send your CV and a motivation letter to christian.specht@inserm.fr, clement.cabriel@espci.fr and ignacio.izeddin@espci.fr
Please feel free to contact us for more information about the offer.