This image of a maximum intensity projection of an E10.5 live mouse embryo was submitted by Sarah Rubin. Taken by light sheet microscopy, the image shows the early stages of skeletal development. In green, Sox9 lineage cells, the earliest marker for skeletal development, can be observed in the somites and face. The surrounding embryonic tissues can be seen in red. Over the course of several days Sox9 lineage cells undergo initial patterning to form the mold for the future skeleton.
Sarah is a PhD candidate in Prof. Elazar Zelzer’s lab in the Weizmann Institute of Science, where she studies cell morphogenesis in embryonic growth plates during development and disease. She previously obtained her MSc in the Zelzer lab, studying morphogenesis of post-natal mouse bones.
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Posted by FocalPlane, on 27 July 2021Here is a selection of interesting news, publications and discussions related to microscopy that happened in the past month. Thank you to our ‘FocalPlane reporters’: Martin Jones, Manish Kumar, Andrey Andreev and Parash Prasad who helped us create this list. Twitter Microscopes and imaging tools: Realising design flaws are unpleasant, but save a lot of
Posted by Rocco D’Antuono, on 20 July 2021During my university time at physics, I specialised in biophysics and started to approach advanced microscopy, but my idea of measurement had always been connected with other instruments’ readouts, not exclusively images. Once obtained my MSc, I started to work in an imaging facility at IFOM (Milan), as a microscopist, becoming later also in charge
Posted by FocalPlane, on 19 July 2021FocalPlane turned one on Thursday 1 July 2021, and we are organising a new image competition to celebrate it with you. Submit your favourite images acquired using any microscopy modality. All the images submitted will be featured on FocalPlane and will be voted on by the community. The image with the most votes will be
Sponsored by Andor, on 8 July 2021ANDOR, a global manufacturer of high performance scientific cameras, spectrographs and microscopy systems, is pleased to announce a co-marketing agreement with Akoya Biosciences Inc., The Spatial Biology Company®. Under this agreement the companies will support their mutual user base within Akoya’s Imaging Innovators (I2) Network. Andor Dragonfly high speed confocal products combined with Akoya’s CODEX® solution
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Microscopy-related articles from our journals
- L-selectin regulates human neutrophil transendothelial migration. Journal of Cell Science 2021 134: jcs.250340
- The 20S proteasome activator PA28γ controls the compaction of chromatin. Journal of Cell Science 2021 134: jcs.257717
- Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart. Development 2021 148: dev.194563
- Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes. Disease Models & Mechanisms 2021 14: dmm046573
- Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila. Biology Open 2021 10: bio052332
Microscopy-related preprint highlights
- InsectBrainDatabase – A unified platform to manage, share, and archive morphological and functional data.
- Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
- Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis. doi: 10.1242/prelights.27402
From the gallery
- Confocal microscopyApply
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- Single plane illumin..ation microscopy (SPIM / Light sheet)Apply
- Total internal refle..ction fluorescence (TIRF) microscopyApply
- Electron microscopyApply
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- Genetic probesApply
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