This false-coloured scanning electron micrograph of two Plasmodium ookinetes (purple) was submitted by Leandro Lemgruber Soares. Plasmodium is a parasitic protozoon that causes Malaria. This motile life form is a fertilised zygote that burrows into the wall of the mosquito midgut in order to develop into an oocyst. This represents one stage in the malaria parasite life cycle. Cellular debris (yellow) from the growth medium is also visible.
Leandro has 20 years of experience working on microscopy, applying light and electron microscopy, super-resolution and cry-microscopy as well as correlative microscopy and image analysis. He has worked in Brazil, Italy, Germany, USA and, for the last 6 years. He established and manages the Glasgow Imaging Facility at the Institute of Infection, Immunity and Inflammation at the University of Glasgow.
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Posted by FocalPlane, on 16 June 2021Hello cell biologists, The BSCB has two looming deadlines for 1) our image competition, and 2) our science writing competition. Deadline for applications is June 30th 2021. Cash prizes awarded to winning entries. For competition details visit BSCB.org. Entries can be sent to Stephen.Robinson@quadram.ac.uk.
Sponsored by Olympus, on 14 June 2021Among recent nanoscopy techniques that break the diffraction limit, single-molecule localization microscopy (SMLM) contributes to major discoveries in medicine and biology. It is now possible to see how subcellular molecular machineries form and behave inside single cells and to quantify single biological molecules such as proteins, nucleic acids, and lipids, at ultralow concentrations inside the
Posted by Afonso Mendes, on 11 June 2021Biomedical research encompasses several fields of expertise involving complex biological topics and technologies. Studying a given subject is a process that takes years, decades, and sometimes a lifetime to complete. Consequently, researchers tend to become highly familiar with a specific subset of scientific topics and experimental approaches. However, they are often confronted with the cumbersome
Posted by FocalPlane, on 11 June 2021Here is a selection of interesting news, publications and discussions related to microscopy that happened in the past two weeks. Thank you to our ‘FocalPlane reporters’: Martin Jones, Manish Kumar, Andrey Andreev and Parash Prasad who helped us create this list. Twitter Microscopes and imaging tools: REALM, adaptive optics for single-molecule localisation https://twitter.com/MarijnSiemons/… Excitation optics
Posted by FocalPlane, on 8 June 2021Today we start a new monthly post. We have asked three researchers to propose their three favourite recently published papers (related to microscopy, of course). You might be up to date with the recent literature in your field of research, but what about other disciplines? We hope this list, provided this month by Claudia Almeida,
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Microscopy-related articles from our journals
- L-selectin regulates human neutrophil transendothelial migration. Journal of Cell Science 2021 134: jcs.250340
- The 20S proteasome activator PA28γ controls the compaction of chromatin. Journal of Cell Science 2021 134: jcs.257717
- Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart. Development 2021 148: dev.194563
- Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes. Disease Models & Mechanisms 2021 14: dmm046573
- Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila. Biology Open 2021 10: bio052332
Microscopy-related preprint highlights
- InsectBrainDatabase – A unified platform to manage, share, and archive morphological and functional data.
- Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
- Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis. doi: 10.1242/prelights.27402
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