Posted on 11 November 2025
Why do some cells age too early? Hutchinson–Gilford Progeria Syndrome (HGPS) is a genetic disorder that causes premature ageing and leads to an average life expectancy of 15 years. It results from a mutation in the nuclear lamina gene LMNA, which compromises the mechanical integrity of the nucleus. Our recent findings show that HGPS patientPosted on 11 November 2025
The oestrogen receptor (ER) is a transcription factor that controls gene expression programs essential for development, reproduction, and cellular health. By binding to specific DNA sequences, ER recruits cofactors and remodels chromatin to regulate transcription. However, despite decades of research, we still lack a fundamental understanding of how ER locates its genomic targets, how itPosted on 11 November 2025
This fully funded PhD project offers the opportunity to investigate how the molecular motor myosin VI (MVI) contributes to DNA repair processes and cancer therapy. Transcription and DNA repair both require dynamic reorganisation of chromatin. Our recent discoveries show that MVI stabilises nuclear structures essential for transcription and may play a similar role at DNA