Postdoctoral Position in Structural and mechanistic investigation of the ciliary trafficking machinery bound to cargo

We are looking for a highly skilled and motivated postdoctoral researcher to work on deciphering the molecular mechanisms of how eukaryotic cells construct cilia organelles through selective recognition and trafficking of cargo proteins. The project will use biochemical and structural biology techniques such as cryo-EM to study how the intraflagellar transport machinery associate with, traffics and releases proteins destined for the cilium.

Job description

Recent work in the laboratory of Professor Esben Lorentzen has used AI-based methods in structural prediction to hypothesize how novel cargo proteins interact with the ciliary trafficking machinery. The goal of this postdoctoral position is to study these interactions using cutting-edge structural biology approaches. The lab is fully equipped with molecular biology and biochemistry facilities, with access to structure determination methods (X-ray crystallography and single-particle cryo-EM) and a high-performance GPU computer cluster for structural biology.

Your profile

The successful candidate should have:

• A Ph.D. degree in a relevant field
• Strong background in structural biology, biochemistry/biophysics, bioinformatics, or related disciplines. Experience in cryo-EM is an advantage.
• Demonstrated research excellence through publications and/or technical achievements
• Strong collaborative skills and the ability to take initiative and responsibility
• Excellent written and verbal communication skills in English

Who we are

The Department of Molecular Biology and Genetics, part of the Faculty of Science and Technology at Aarhus University, conducts research in Molecular Medicine, Systems Biology, Structural Biology, Plant Molecular Biology, and Quantitative Genetics. The department hosts 220 full-time scientific staff and 140 Ph.D. students.
Read more about the department on our webpage: https://mbg.au.dk/en/

What we offer

Aarhus offers an exceptional quality of life, combining:
• Rich cultural scene and vibrant city life and easy access to beautiful nature
• Safe, family-friendly environment
• Excellent work-life balance
• International atmosphere
For more information about working at Aarhus University, visit http://talent.au.dk/working-at-aarhus-university/

Contact information

For further information, please contact: Professor, Esben Lorentzen, el@mbg.au.dk

Deadline

Applications must be received no later than 10th of Dec 2025.