MRC DiMeN Doctoral Training Partnership: Stopping premature ageing: Investigating the role of actomyosin mediated nuclear force feedback in cell homeostasis.

Posted on 11 November 2025

Why do some cells age too early? Hutchinson–Gilford Progeria Syndrome (HGPS) is a genetic disorder that causes premature ageing and leads to an average life expectancy of 15 years. It results from a mutation in the nuclear lamina gene LMNA, which compromises the mechanical integrity of the nucleus. Our recent findings show that HGPS patient