Doctoral Research Associate Wissenschaftliche/r Mitarbeiter/in (salary level 13 TV-L, 65%) in the field of developmental cell biology

About the Project

This project investigates how mesenchymal cells form a continuous muscle layer that envelops an organ through contact-dependent collective migration and nematic alignment. We focus on the adhesion GPCR Cirl (Latrophilin), which we have identified as a key regulator of cell movement and alignment during formation of the Drosophila testis sheath. Using live imaging and genetic approaches, we aim to elucidate how Cirl controls migratory behavior, protrusive dynamics, and cytoskeletal organization, and whether it acts via G-protein signaling, adhesive interactions, or mechanosensory mechanisms. Ultimately, this work seeks to understand how molecular processes give rise to emergent, tissue-scale morphogenesis.

For this project, we are seeking a candidate with a strong interest in cell and developmental biology. You will investigate the cellular and molecular mechanisms of collective mesenchymal migration and tissue morphogenesis using Drosophila melanogaster as a model system. The project integrates genetics, advanced live imaging, and quantitative cell biological approaches to uncover how adhesion GPCR signaling translates cell–cell contact into coordinated migration and alignment. Further, you will have the opportunity to join the SFB1348 grad school (https://www.uni-muenster.de/SFB1348/en/graduate_school/index.html).

Your tasks:

• The position is tied to working towards a doctorate (Ph.D.) in the field of developmental cell biology and genetics.
• In the three-year project, mechanistic questions related to organ morphogenesis and cell migration in Drosophila melanogaster are to be addressed using genetic, molecular and imaging techniques.
• Teaching duties involve supervision of undergraduate students at the Bachelor and Master level.

Our expectations:

• The prerequisite for this appointment is a M.Sc. degree in biology, biochemistry or another related discipline.
• Candidates with a strong background in cell or developmental biology, molecular biology or genetics are encouraged to apply.
• Applications from candidates interested in quantitative imaging are especially welcome.
• A good command of written and spoken English is essential.
• German language skills would be advantageous but are not a requirement.

About the MIC, Muenster

The Multiscale Imaging Centre, MIC for short, is the central research building of the Cells in Motion Interfaculty Centre at the University of Münster and is located on Röntgenstraße 16, right in the middle of our university’s life and natural sciences campus. Working groups from various faculties are based here, bringing together a core of our wide range of expertise in biomedical imaging, as well as the corresponding technologies which we use to investigate the behaviour of cells in organisms. Our research building also provides a central meeting point for scientists from Münster as well as international guests involved in the research field of cell dynamics and imaging.

Applications should include a motivation letter and a curriculum vitae. We look forward to receiving your application by 2026-01-15. Applications should be sent electronically, as one single PDF file, to:

Dr. Maik Bischoff
Institute of Integrative Cell Biology and Physiology
The University of Münster
Multiscale Imaging Center
Röntgenstraße 16
D-48149 Münster, Germany

Email: maik.bischoff@uni-muenster.de

More information about the lab: https://www.bischofflab.com/