Cryo-EM Specialist

We invite applications for a Research Associate (Cryo-EM specialist) position, jointly shared by Harvard Faculty of Arts and Sciences (FAS) and Harvard Medical School. This Research Associate position will be hosted at Harvard Medical School with responsibilities split between the two campuses. This annually appointed academic role advances discovery in structural biology by providing support and training for researchers seeking to learn cryo-EM, serving as an interface between the instruments and a vibrant scientific community.

Responsibilities to FAS will take place in the newly established Cryo-EM imaging core under the Harvard Center for Biological Imaging (HCBI). This is the first cryogenic imaging facility dedicated to biological samples on Harvard’s Cambridge campus. This facility houses sample preparation devices (Vitrobot Mark IV, Wohlwend High Pressure Freezer, Leica EM AFS2 Freeze Substitution), and a Glacios 2 cryo-electron microscope with X-FEG, fringe-free imaging, Selectris energy filter and Falcon4i direct electron detector.

Responsibilities to Harvard Medical School will take place at the Harvard Cryo-EM Center for Structural Biology (HCCSB): a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, Massachusetts General Bringham, and Harvard FAS to provide state-of-the-art cryo-EM instrumentation and expertise for the structural biology community. This Facility houses two Titan Krios 300 kV microscopes and a Talos Arctica 200 kV microscope, with a next-generation Titan Krios 5 scheduled for installation in 2026. We also house two Vitrobot Mark IVs for sample preparation and two Aquilos 2 Cryo-FIBs to produce lamellae for cryo-ET.

The successful candidate, working closely with fellow imaging scientists at the HCBI and the HCCSB at Harvard Medical School will enhance and expand cryo-EM capabilities across Harvard, and the greater Boston scientific ecosystem.