PhD Astrocyte–Synapse Topology, Regulation Adaptability through Light, X-ray and Electron Microscopy

The Cryo-ASTRALXEM PhD project aims to decipher the nanoscale organization of astrocyte–synapse interfaces using a multimodal cryogenic imaging workflow. You will combine cryogenic X-ray holographic nanotomography, visible light microscopy, cryogenic X-ray fluorescence, and cryo-electron tomography to bridge scales from whole astrocytes within their native context all the way down to molecular resolution.
The project also includes establishing multimodal correlation workflows and collaborating with machine learning specialists to implement advanced computational analysis, including ML-based segmentation and 3D quantitative mapping.