PhD student in Neuroscience

In this project, you will contribute to both engineering and neurobiology. First, you will help build a light-sheet microscope optimized for voltage imaging at the single-cell and subcellular level in live larval zebrafish (reference↗). The development of this system will be supported by experienced colleagues and the Biology Image Center↗ team. Once the microscope is established, you will use it to investigate the electrophysiological properties of cerebellar Purkinje cells with advanced voltage indicators such as Voltron2. The ultimate goal is to uncover how Purkinje cells alter their dendritic signaling and spiking characteristics under different sensory or chemogenetic conditioning paradigms, and to determine how these changes may be mediated through intrinsic plasticity or brain state.