Two post-doctoral positions to study the mechanisms of epithelial homeostasis

Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap (Institute for Molecular Bioscience, IMB, University of Queensland).

Our broad aim is to elucidate how epithelia respond to sporadic cell injury: identifying the mechanisms that allow healthy cells to identify and eliminate injured cells; and characterizing the pathological consequences when these homeostatic mechanisms fail. This builds on our recent discovery that epithelia have distinct mechanisms to detect and eliminate apoptotic cells; these integrate mechanical and chemical cell-cell communication between apoptotic cells and their surrounding neighbours (e.g. Current Biology 2021: PMID 33581074; Developmental Cell 2023: PMID 37647898). Important questions include a comprehensive analysis of the homeostatic pathways that epithelia elicit in response to apoptotic cells; understanding how cell-cell signaling works as a dynamic system; and testing how disease can arise when these homeostatic processes are disturbed.

The team uses a multi-disciplinary approach, working with national and international collaborators, to combine experimental cell biology, quantitative approaches to cell dynamics, biophysical assays and animal models of inflammation.

For one position we especially seek candidates with experience in the cell biology of apoptosis and inflammation. For the second position, it would be valuable to have experience in live-cell optical microscopy, biosensor technology, and/or quantitative analysis of dynamic systems. It is anticipated that successful candidates will participate in mentorship of students, and professional development through networking, conferences and grant-writing, as appropriate.

Appointments will be for 2 years, with the potential for extension depending on funding. These are outstanding opportunities for ambitious scientists to develop interdisciplinary research expertise and grow their scientific profile.

We are flexible in: 1) Tailoring projects to the experience and interest of candidates; and 2) a start date to join us.

For further details, see: https://uq.wd3.myworkdayjobs.com/uqcareers/job/St-Lucia-Campus/Postdoctoral-Research-Fellow-Research-Officer—Cell-Biology_R-47106