Back to the density: using Surface Morphometrics to measure organelle membrane thickness in cryo-electron tomography

Posted by Michaela Medina, on 18 March 2026

Surface Morphometrics is an open-access software that extracts quantitative information of membrane ultrastructure from high resolution cryo-electron tomography (cryo-ET) data. This tooling allows for the study of organelles in their native environment across large populations in an automated fashion. The Surface Morphometrics pipeline reconstructs three-dimensional triangular surface meshes to model and quantify the cellular membrane