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Imaging spotlight: Lock-in-SIM

Posted by FocalPlane, on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.

Microscopy preprints: bioimage analysis

Posted by FocalPlane, on 29 December 2025

Here is a curated selection of preprints published (or updated) recently. In this post we focus specifically on bioimage analysis and data management.

Imaging spotlight: u-Segment3D

Posted by FocalPlane, on 11 December 2025

In this paper highlight, we learn about u-Segment3D, a software framework developed by Felix Zhou and Gaudenz Danuser and colleagues.

Federal Super-Resolution Network in Argentina

Posted by Lucía Lopez, on 4 December 2025

About twenty years ago, a series of methods known today as super-resolution microscopy were discovered. Since then, super-resolution microscopy has become a powerful tool for discovery in cell biology, biomedicine, and biophysics. However, the complexity of some methods, high costs, and demanding sample preparation protocols have hindered their widespread application. In Argentina, the group led

Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS)

Posted by FocalPlane, on 2 December 2025

In this paper highlight, we learn more about VIPS, a method developed by Srigokul Upadhyayula, Ruixuan Gao and colleagues.

Exploring the Microcosmos through Foldscope-Frugal Science Microscopy in Focus

Posted by Aarushi Verma, on 18 July 2025

The third annual iteration of the Lodha Genius Programme at Ashoka University, Sonepat, featured a month-long workshop series for students of grades 9 and 10, introducing them to the intricate diversity of the microscopic world through the use of a frugal science innovation—the Foldscope. Much like the initiative described in this article on IndiaBioscience, this

Event carbon calculator

Posted by Teodora Andreea Rînciog, on 30 June 2025

I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your event’s carbon footprint in five minute or less. Our event carbon calculator provides insights into the main drivers of your meeting’s greenhouse gas emissions, offers reduction scenarios to test and provides

Annotating Images in Cellpose

Posted by Lea Kabjesz, on 5 June 2025

In this blog post, I’ll show you how to manually annotate cells in 2D and 3D images using the Cellpose Graphical User Interface (GUI). Manual annotation is a key step in many bioimage analysis workflows. It allows you to create labeled data that can serve as a reference for evaluating segmentation quality – or even

Highlighting signalling biosensors 1.

Posted by Greg Redpath, on 16 January 2025

Why there is interest in signalling biosensors, considerations for using biosensors, and the original biosensor, GFP. Why write about signalling biosensors? In my first postdoctoral position, I was introduced to the concept of endosomal signalling- a way for receptor signalling outcomes to be changed by delivering a signal to different regions of the cell. I

An interview with Lina El Hajji

Posted by FocalPlane, on 9 January 2025

Lina was one of the three-minute talk presenters at our science communication event, SciCommConnect. At the event, which we co-hosted with the Node and preLights, we were treated to fantastic talks on a range of topics. Lina has kindly allowed us to share her presentation and we caught up with Lina to learn more about

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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