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Imaging spotlight: Minimally invasive live tissue clearing with SeeDB-Live

Posted by , on 1 April 2026

In this paper highlight from Shigenori Inagaki and Takeshi Imai, we learn about SeeDB-Live, a methodology for applying tissue clearing to live-cell imaging.
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Back to the density: using Surface Morphometrics to measure organelle membrane thickness in cryo-electron tomography

Posted by , on 18 March 2026

Surface Morphometrics is an open-access software that extracts quantitative information of membrane ultrastructure from high resolution cryo-electron tomography (cryo-ET) data. This tooling allows for the study of organelles in their native environment across large populations in an automated fashion. The Surface Morphometrics pipeline reconstructs three-dimensional triangular surface meshes to model and quantify the cellular membrane
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Imaging spotlight: PhotoFiTT

Posted by , on 2 March 2026

In this paper highlight, we learn about PhotoFiTT, a framework for measuring phototoxicity in live-cell fluorescence microscopy. Mario Del Rosario and Estibaliz Gómez-de-Mariscal, the co-first authors of PhotoFiTT answer our questions about their work.
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Imaging spotlight: ShapeSpaceExplorer

Posted by , on 5 February 2026

In this paper highlight, we learn about ShapeSpaceExplorer, a tool for measuring cell shape of migrating cells, developed by Samuel Jefferyes, Anne Straube and colleagues.
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JCS snapshot: Tracking coordinated cellular dynamics in time-lapse microscopy with ARCOS.px

Posted by , on 29 January 2026

In our latest JCS snapshot we hear from Maciej Dobrzyński, who, together with Benjamin Grädel and colleagues, developed ARCOS.px, a software tool to automatically identify and track coordinated dynamic cellular events in time-lapse microscopy movies.
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Imaging spotlight: Lock-in-SIM

Posted by , on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.
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Microscopy preprints: bioimage analysis

Posted by , on 29 December 2025

Here is a curated selection of preprints published (or updated) recently. In this post we focus specifically on bioimage analysis and data management.
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Imaging spotlight: u-Segment3D

Posted by , on 11 December 2025

In this paper highlight, we learn about u-Segment3D, a software framework developed by Felix Zhou and Gaudenz Danuser and colleagues.
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Federal Super-Resolution Network in Argentina

Posted by , on 4 December 2025

About twenty years ago, a series of methods known today as super-resolution microscopy were discovered. Since then, super-resolution microscopy has become a powerful tool for discovery in cell biology, biomedicine, and biophysics. However, the complexity of some methods, high costs, and demanding sample preparation protocols have hindered their widespread application. In Argentina, the group led
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Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS)

Posted by , on 2 December 2025

In this paper highlight, we learn more about VIPS, a method developed by Srigokul Upadhyayula, Ruixuan Gao and colleagues.
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