Featured image with Ciarán Butler Hallissey

Posted by FocalPlane, on 13 September 2024

Our featured image, acquired by Ciarán Butler Hallissey, is a maximum-intensity projection of rat hippocampal neurons processed with ultrastructure expansion microscopy (U-ExM) and captured with a spinning disk confocal microscope. Find out more about the image and Ciarán’s research below. More about the image: Expansion microscopy physically increases the size of your sample to improve

Advances in Expansion Microscopy

Posted by Victoria Alonso, on 4 August 2023

Expansion microscopy was introduced in 2015 by Boyden and his team, revolutionizing the way we see biological samples under a microscope1. Taking advantage of the power of physical enlargement, ExM pushes spatial resolution beyond the diffraction limit, allowing us to observe intricate details at previously unimaginable levels. The underlying principle of ExM lies in a