Volume EM Visualization of 3D Synaptic Ultrastructure in Postmortem Human Prefrontal Cortex

Posted by Janithri Wickramanayake, on 31 October 2025

by J.R. Glausier1, M. Maier1, J. Kozel1, C. Bouchet-Marquis2, K. Wu2, et al., 1University of Pittsburgh and 2Thermo Fisher Challenge Synaptic function and ultrastructure are intrinsically coupled; thus, volume electron microscopy (vEM) offers the ability to quantitatively interrogate multiple ultrastructural correlates of function within the individual synapses that populate a brain volume. By applying vEM