Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis

Posted by Manuel Mendoza, on 26 January 2026

Melike Lakadamyali, Jérôme Solon and Manuel MendozaAs cells divide during development, their size evolves dramatically while DNA content remains constant. This raises a fundamental question: does chromosome compaction adjust to these size changes so that genomes are still segregated faithfully? This question has been with us for a long time. More than a decade ago,