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Imaging spotlight: the axonal membrane-associated periodic skeleton

Posted by , on 5 March 2026

In this paper highlight, Nick Boyer takes us through the key results and imaging techniques that they used in their research dissecting the axonal membrane-associated periodic skeleton with Rohan Sharma, Christophe Leterrier, Subhojit Roy and colleagues.
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Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET

Posted by , on 21 January 2026

In this paper highlight from Jana Kroll and colleagues, we hear about their research combing optogenetic stimulation with plunge freezing and cryo-electron tomography to study synaptic vesicle fusion.
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Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography

Posted by , on 13 January 2026

In this paper highlight, Carles Bosch, Ana Diaz, Adrian A. Wanner and Andreas T. Schaefer (on behalf of all authors) describe how they use nondestructive X-ray tomography to map mouse brain tissue ultrastructure . 
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Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation 

Posted by , on 11 December 2025

In this post, I'll told you the "ins and outs" of our last publication in JCB about lysosomal tubulation in response to damage.
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Volume EM Visualization of 3D Synaptic Ultrastructure in Postmortem Human Prefrontal Cortex

Posted by , on 31 October 2025

by J.R. Glausier1, M. Maier1, J. Kozel1, C. Bouchet-Marquis2, K. Wu2, et al., 1University of Pittsburgh and 2Thermo Fisher Challenge Synaptic function and ultrastructure are intrinsically coupled; thus, volume electron microscopy (vEM) offers the ability to quantitatively interrogate multiple ultrastructural correlates of function within the individual synapses that populate a brain volume. By applying vEM
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Featured image with Ludovica Altieri

Posted by , on 15 August 2025

Our featured image, acquired by Ludovica Altieri, shows murine primary cortical neurons developing interconnections. The cells are stained for neuronal tubulin (TUJI antibody, cyan) and DNA (DAPI, blue). Cultures were prepared by dissecting cortices from mouse embryos (E18), then mechanically dissociating single cells for plating. Explanted primary neurons placed in culture regress several stages back,
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Microscopy preprints - applications in biology

Posted by , on 21 February 2025

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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Microscopy preprints - bioimage analysis

Posted by , on 29 November 2024

Here is a curated selection of preprints published recently. In this post, we focus specifically on bioimage analysis and data management.
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Microscopy preprints - applications in biology

Posted by , on 15 November 2024

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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Featured image with Ciarán Butler Hallissey

Posted by , on 13 September 2024

Our featured image, acquired by Ciarán Butler Hallissey, is a maximum-intensity projection of rat hippocampal neurons processed with ultrastructure expansion microscopy (U-ExM) and captured with a spinning disk confocal microscope. Find out more about the image and Ciarán’s research below. More about the image: Expansion microscopy physically increases the size of your sample to improve
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