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Featured image with Jyoti Maddhesiya

Posted by FocalPlane, on 8 November 2024

Our featured image, acquired by Jyoti Maddhesiya, is a laser scanning confocal image of H9c2 cardiomyoblast cells. The green shows BMP7 in the cytoplasm, the blue highlights the nuclei and the cytoskeleton protein F-actin is labelled in red. The cells were transfected with a BMP7 construct and fixed and labelled 48 hours post transfection. The

Featured image with… our JCS cover competition winner Antara Chakraborty

Posted by FocalPlane, on 30 October 2024

We are delighted to announce that our cover competition winner is Antara Chakraborty. Antara’s winning image ‘Breaking symmetry’ is the cover image for Journal of Cell Science’s Special Issue: Imaging Cell Architecture and Dynamics; you can explore the table of contents here. The image shows a mouse embryonic fibroblast labelled with phalloidin (actin – green),

Featured image with David Gaboriau

Posted by FocalPlane, on 11 October 2024

Our featured image, acquired by David Gaboriau, shows human fibroblasts with mitochondria (Tom20) in yellow, alpha tubulin in pink and actin in grey. It’s a 3D-SIM image taken on a Zeiss Elyra PS.1, reconstructed in Zen and presented as a maximum intensity projection. Find out more about David’s research below: Research career so far: I’m originally a

Featured image from Lama Khalaily

Posted by FocalPlane, on 27 September 2024

Our featured image, acquired by Lama Khalaily, captures the intricate structure of a mouse cochlea’s hearing organ, highlighting two essential cell types involved in hair cell regeneration. The image reveals four organized rows of sensory hair cells (red), responsible for hearing, intertwined with non-sensory supporting cells (green). These supporting cells play diverse roles in the

Featured image with Ciarán Butler Hallissey

Posted by FocalPlane, on 13 September 2024

Our featured image, acquired by Ciarán Butler Hallissey, is a maximum-intensity projection of rat hippocampal neurons processed with ultrastructure expansion microscopy (U-ExM) and captured with a spinning disk confocal microscope. Find out more about the image and Ciarán’s research below. More about the image: Expansion microscopy physically increases the size of your sample to improve

Featured image with Shivangi Verma

Posted by FocalPlane, on 30 August 2024

Our featured image, acquired by Shivangi Verma, gives us a peek into the brain of a zebrafish. It depicts neurons in the whole brain of a larva expressing GCaMP6f, a fluorescent reporter of neuronal activity, using a pan-neuronal promoter. A 10-day old transparent homozygous albino larva was embedded in agarose and imaged using ZEISS Lightsheet

Featured image with Marina Schernthanner

Posted by FocalPlane, on 16 August 2024

Our featured image, acquired by Marina Schernthanner, shows the hair follicles of a young (postnatal day 9) C57B6 mouse’s back skin. By using ethanol-based tissue clearing, Mariana stained fixed whole-mount tissue samples of the murine skin after removing the surface haircoat and subcutaneous fat layer. LYVE-1 (orange) marks the lymphatic vasculature, Keratin-14 (red) highlights the

Featured image with Upasana Gupta

Posted by FocalPlane, on 2 August 2024

Our featured image, acquired by Upasana Gupta, represents the cellular architecture of zebrafish (larva) eye. The tissue was prepared by paraformaldehyde fixation of a 4-day post fertilisation larva, followed by staining with Hoechst nuclear stain. The sample was imaged and processed using Leica SP8 confocal microscope and Leica software at the Bio-imaging facility at the

Featured image with Jovan Brockett

Posted by FocalPlane, on 19 July 2024

Our featured image, acquired by Jovan Brockett, shows a Drosophila melanogaster embryo undergoing syncytial nuclear divisions during early embryonic development. It was prepared using PFA fixation and hand dissected to remove the outer vitelline membrane. The image was captured using a Nikon Ti-E system fitted with a Yokagawa CSU-X1 spinning disk head, Hamamatsu Orca Flash

Featured image with Hoang Anh Le

Posted by FocalPlane, on 5 July 2024

Our featured image, acquired by Hoang Anh Le, shows an Ewing’s sarcoma cancer cell plated on a fibronectin-coated surface. The cell was fixed with 4% formaldehyde and stained using phalloidin (white) and DAPI (in pink). The sample was imaged using a confocal Zeiss 880 microscope with Airyscan.

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Microscopy-related articles from our journals

HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples Development 2024 151: dev202307
filoVision – using deep learning and tip markers to automate filopodia analysis J Cell Sci 2024 137: jcs261274
C omputational tools for quantifying actin filament numbers, lengths, and bundling Biology Open 2024 13: bio.060267

Microscopy-related preprint highlights

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