cryo-electron tomography

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Microscopy preprints: applications in biology

Posted by FocalPlane, on 29 May 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.

Back to the density: using Surface Morphometrics to measure organelle membrane thickness in cryo-electron tomography

Posted by Michaela Medina, on 18 March 2026

Surface Morphometrics is an open-access software that extracts quantitative information of membrane ultrastructure from high resolution cryo-electron tomography (cryo-ET) data. This tooling allows for the study of organelles in their native environment across large populations in an automated fashion. The Surface Morphometrics pipeline reconstructs three-dimensional triangular surface meshes to model and quantify the cellular membrane

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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