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Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis

Posted by , on 26 January 2026

Melike Lakadamyali, Jérôme Solon and Manuel MendozaAs cells divide during development, their size evolves dramatically while DNA content remains constant. This raises a fundamental question: does chromosome compaction adjust to these size changes so that genomes are still segregated faithfully? This question has been with us for a long time. More than a decade ago,
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Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET

Posted by , on 21 January 2026

In this paper highlight from Jana Kroll and colleagues, we hear about their research combing optogenetic stimulation with plunge freezing and cryo-electron tomography to study synaptic vesicle fusion.
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Imaging spotlight: U-ExM atlas of microbial eukaryotes

Posted by , on 20 January 2026

In this paper highlight from Hiral Shah and colleagues, we learn about their ultrastructure expansion microscopy (U-ExM) atlas of over 200 cultured planktonic eukaryotes. This post includes technical advice for ExM users and highlights the open-access resource that they have generated for cytoskeleton or marine microorganism aficionados (and microscopy sciart lovers!)
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Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy

Posted by , on 16 January 2026

In this highlight, Kruno Vukušić and Iva M. Tolić describe how they use multi-scale live lattice light-sheet and super-resolution microscopy to decipher the earliest steps of chromosome congression.
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Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography

Posted by , on 13 January 2026

In this paper highlight, Carles Bosch, Ana Diaz, Adrian A. Wanner and Andreas T. Schaefer (on behalf of all authors) describe how they use nondestructive X-ray tomography to map mouse brain tissue ultrastructure . 
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Imaging spotlight: Lock-in-SIM

Posted by , on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.
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Imaging spotlight: u-Segment3D

Posted by , on 11 December 2025

In this paper highlight, we learn about u-Segment3D, a software framework developed by Felix Zhou and Gaudenz Danuser and colleagues.
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Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS)

Posted by , on 2 December 2025

In this paper highlight, we learn more about VIPS, a method developed by Srigokul Upadhyayula, Ruixuan Gao and colleagues.
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