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Imaging spotlight: visualising synaptic vesicle fusion by cryo-ET

Posted by FocalPlane, on 21 January 2026

In this paper highlight from Jana Kroll and colleagues, we hear about their research combing optogenetic stimulation with plunge freezing and cryo-electron tomography to study synaptic vesicle fusion.

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography

Posted by FocalPlane, on 13 January 2026

In this paper highlight, Carles Bosch, Ana Diaz, Adrian A. Wanner and Andreas T. Schaefer (on behalf of all authors) describe how they use nondestructive X-ray tomography to map mouse brain tissue ultrastructure .

Microscopy preprints – applications in biology

Posted by FocalPlane, on 19 September 2025

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.

Illuminating the Brain: Microscopy Techniques in Neuroscience and My Applications in the Lab

Posted by Sally Horton, on 23 June 2025

Understanding the brain’s complexity requires more than theory or behaviour; it demands a look at the smallest units of structure and function. Microscopy has long been a cornerstone of neuroscience, evolving rapidly from conventional optical methods to cutting-edge super-resolution and electron techniques. This article explores how confocal microscopy, STORM, and electron microscopy are advancing our

Workshop report: France BioImaging - Advanced Training on Light-Sheet Microscopy

Posted by Clara Hayn, on 22 May 2025

From November 4th to 7th, 2024, I had the privilege to attend the Advanced Training on Light-Sheet Microscopy‘s Principles and Applications to Neuroscience and 3D Cell Culture at France BioImaging in Bordeaux. This comprehensive training, rich in both theoretical and practical knowledge, provided an exceptional platform for learning and engaging with experts in the field.

Advantages of LED Illumination for Neuroscience Research

Sponsored by CoolLED, on 26 September 2024

LED microscopy illumination has disrupted traditional approaches to high-speed imaging and optogenetic stimulation for neuroscience, and the CoolLED Support Team are available to help researchers understand which filters, light sources and other components are right for each individual setup.

An interview with Maribel Torres Velázquez

Posted by Mariana De Niz, on 6 August 2024

MiniBio: Maribel Torres Velázquez is a NURTURE postdoctoral fellow in the lab of Prof. Gregory Schwartz at the Feinberg School of Medicine at Northwestern University, where she uses microscopy to study the retina-to-brain circuitry. Specifically, she aims to uncover the retina-brain connectivity map by identifying to which unique brain areas different retinal ganglion cell sub-types

Microscopy preprints – applications in biology

Posted by FocalPlane, on 19 April 2024

In this post, we share preprints that use microscopy tools to answer questions in biology.

Featured image with Thibault Dhellemmes and Jérémie Teillon

Posted by FocalPlane, on 1 March 2024

Our featured image shows the full morphology of Relaxin-3 neurons in an entire adult mouse brain. To observe the full depth of this brain, it was made transparent by applying an optical clearing technique called Adipoclear. The sample was observed on an Ultramicroscope II light sheet microscope and is a maximum intensity projection over the

Enhancing Global Access: interview with CZI grantee Michelle Itano

Posted by Mariana De Niz, on 24 January 2024

ENHANCING THE ROLE OF A MICROSCOPY CORE FACILITY TO CATALYSE BIOMEDICAL RESEARCH Michelle Itano is a cellular biophysicist and Director of the University of North Carolina Chapel Hill Neuroscience Microscopy Core. Her project for the Cycle 1 Imaging Scientists CZI funding call aims to actively engage and grow collaboration between researchers and computer scientists to

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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Microscopy-related articles from our journals

Microscopy-related preprint highlights

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