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Seeing Chromatin Scaling with Cell Size, from Interphase to Mitosis

Posted by Manuel Mendoza, on 26 January 2026

Melike Lakadamyali, Jérôme Solon and Manuel MendozaAs cells divide during development, their size evolves dramatically while DNA content remains constant. This raises a fundamental question: does chromosome compaction adjust to these size changes so that genomes are still segregated faithfully? This question has been with us for a long time. More than a decade ago,

An interview with Andrés Di Paolo

Posted by Mariana De Niz, on 27 July 2022

MiniBio: Andrés Di Paolo holds a hybrid position as a postdoctoral researcher and as a member of a microscopy core facility, involving several institutions including Institut Pasteur Montevideo, Hospital de Clínicas from UdelaR and Instituto de Investigaciones Biológicas Clemente Estable (IIBCE). He is currently involved in the development of the first super-resolution microscope (based on STORM)

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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