PDRA in Microscopy of Mitochondrial Copy-Number

Posted by , on 1 September 2020

Closing date 14 September 2020

Applications are invited for a 2-year PostDoc joint between the labs of Patrick Chinnery (Cambridge Mitochondrial Biology Unit/Clinical Neuroscience) and Nick Jones (Imperial Maths) using microscopy to study the control of mitochondrial genome copy-number.

Cells control the copy-number of their mitochondrial DNA (mtDNA) yet the process of this control has been poorly characterised. Through a combination of microscopy, image analysis and some flow-cytometry the appointee will attempt to understand and perturb this system. Beyond being of fundamental relevance to our biological understanding; the character of control of mtDNA defines the rate and manner in which mutant mtDNA expands through cellular populations. The expansion of mutant mtDNA is implicated in ageing: thus the project seeks to identify some of the basic mechanisms of ageing. The project is a close collaboration between two groups that both have a track record of working at the interface between experiment and theory and aligns with another PDRA and 2 PhDs joint between our groups.

Candidates might have backgrounds in experimental biological physics/biophysics or quantitative biology/microscopy. The core skills will be single-cell microscopy with some image analysis. The appointee will join the Centre for the Mathematics of Precision Healthcare, the Cambridge Mitochondrial Biology unit and a new subgrouping in Imperial Mathematics on Single Cell theory and data. 

The appointment will be principally experimental and the experiments will be undertaken in Cambridge.

We welcome candidates from all backgrounds and value a supportive environment prioritising purposeful happiness. We anticipate an ~October/November 2020 start.

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