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Microscopy preprints – new tools and techniques in imaging

Posted by FocalPlane, on 9 January 2026

Here is a curated selection of preprints posted recently on new tools and techniques in imaging. Let us know if we are missing any recent preprints that are on your reading list!

Imaging spotlight: Lock-in-SIM

Posted by FocalPlane, on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.

Featured image with Christina Daly

Posted by FocalPlane, on 6 January 2026

Our featured image, acquired by Christina Daly, is of an E9.5 murine neural tube. The embryo was fixed in 4% Paraformaldehyde, embedded in agarose, and vibratome-sectioned at 100 mm thickness. The sections were stained with for F-actin with phalloidin and imaged on a Nikon A1R confocal.

Microscopy preprints: bioimage analysis

Posted by FocalPlane, on 29 December 2025

Here is a curated selection of preprints published (or updated) recently. In this post we focus specifically on bioimage analysis and data management.

The Company of Biologist Workshop - Democratising Microscopy in Latin America: Imaging Across Scales and Regions

Posted by Helen Zenner, on 22 December 2025

In October, I was lucky enough to attend The Company of Biologist Workshop – Democratising Microscopy in Latin America: Imaging Across Scales and Regions. The organisers, Constadina Arvanitis, Mario Del Rosario, Helena De la Torre, Mariana De Niz, Maria Fernanda Latorre Barragán and Licyel Lenny Paulas Condori, put together an incredible programme featuring top researchers

Vote for your favourite 'Featured image' from 2025

Posted by FocalPlane, on 19 December 2025

Throughout 2025, we highlighted some fantastic images and researchers in our 'Featured image' series. Here is your chance to vote for your favourite.

OMERO Outputs: Insights from the 4th BioHackathon 2025

Posted by Lea Kabjesz, on 17 December 2025

Hi all! Today I would like to share my experience participating in my first BioHackathon and point you to some new exciting features coming soon to the bioimaging software OMERO. If you are interested in participating in a hackathon yourself, but don’t know what to expect or where to start, I have prepared some insights

Microscopy preprints - applications in biology

Posted by FocalPlane, on 12 December 2025

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.

Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation

Posted by talcualmal, on 11 December 2025

In this post, I'll told you the "ins and outs" of our last publication in JCB about lysosomal tubulation in response to damage.

Imaging spotlight: u-Segment3D

Posted by FocalPlane, on 11 December 2025

In this paper highlight, we learn about u-Segment3D, a software framework developed by Felix Zhou and Gaudenz Danuser and colleagues.

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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