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Imaging spotlight - How to divide without a ring: a mechanical ratchet drives unilateral cytokinesis

Posted by , on 10 February 2026

In this paper highlight, Jan Brugués and Alison Kickuth discuss the microscopy and microrheology techniques that they used in their research dissecting the mechanics of cytokinesis. What are the key results from your paper? Many early embryonic cells divide without forming a closed actomyosin ring, raising a fundamental mechanical puzzle: how can an open-ended, contractile
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Workshop report: EMBO Course on Image Processing in Cryo-EM

Posted by , on 9 February 2026

Freya Cardozo shares her workshop report from the EMBO course on Imaging Processing in Cryo-EM. Freya's attendance was supported with a JCS-FocalPlane Training Grant.
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Imaging spotlight: ShapeSpaceExplorer

Posted by , on 5 February 2026

In this paper highlight, we learn about ShapeSpaceExplorer, a tool for measuring cell shape of migrating cells, developed by Samuel Jefferyes, Anne Straube and colleagues.
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Microscopy preprints – applications in biology

Posted by , on 23 January 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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Cytoneme Imaging Tips and Tricks

Posted by , on 19 January 2026

There has been a growing interest in visualizing long and thin membrane extensions. The field of intercellular connections has exploded, with elegant bioimaging studies focusing on structures like cytonemes, tunneling nanotubes (TNTs), intercellular/cytokinetic bridges (IB/CBs), and migrasomes. This enhanced interest in the intercellular communication facilitated by these extensions is largely due to the recent technological
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Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy

Posted by , on 16 January 2026

In this highlight, Kruno Vukušić and Iva M. Tolić describe how they use multi-scale live lattice light-sheet and super-resolution microscopy to decipher the earliest steps of chromosome congression.
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JCS snapshot: the endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology

Posted by , on 14 January 2026

In our latest JCS snapshot we hear from Sebabrata Maity, who, together with Oishee Chakrabarti and colleagues, discovered that the endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology.
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JCS snapshot - Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation

Posted by , on 12 January 2026

In our latest JCS snapshot we hear from Anne Müsch, who, together with David Cohen and Francisco Lázaro-Diéguez, discovered that bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation.
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Imaging spotlight: Lock-in-SIM

Posted by , on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.
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Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation 

Posted by , on 11 December 2025

In this post, I'll told you the "ins and outs" of our last publication in JCB about lysosomal tubulation in response to damage.
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