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Imaging spotlight: Altair-LSFM

Posted by , on 9 March 2026

In this paper highlight from Kevin Dean and colleagues, we learn about Altair-LSFM, a light-sheet fluorescence microscope that they designed so it can be built and operated in biology labs without needing a full-time optical engineer.
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Microscopy preprints - applications in biology

Posted by , on 9 March 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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JCS snapshot: Redefining colocalization analysis with a novel phasor mixing coefficient

Posted by , on 6 March 2026

In our latest JCS snapshot we hear from Owen Puls, who together with Teng-Leong Chew and team define a new strategy for quantifying biological association that leverages multispectral imaging and phasor analysis, termed the phasor mixing coefficient (PMC). In this snapshot, Owen takes us through the key findings from their research.
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Imaging spotlight: the axonal membrane-associated periodic skeleton

Posted by , on 5 March 2026

In this paper highlight, Nick Boyer takes us through the key results and imaging techniques that they used in their research dissecting the axonal membrane-associated periodic skeleton with Rohan Sharma, Christophe Leterrier, Subhojit Roy and colleagues.
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JCS snapshot: Suppressing microtubule detyrosination augments AAV2 endosomal escape & gene delivery

Posted by , on 19 February 2026

In our latest JCS snapshot we hear from Shefali Tripathi, who, together with Nitin Mohan, Giridhara Jayandharan and team, found that suppressing microtubule detyrosination augments adeno-associated virus 2 endosomal escape and gene delivery.
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JCS snapshot: RNP1A regulates cell shape in Dictyostelium amoebas

Posted by , on 12 February 2026

In our latest JCS snapshot we hear from Mark Jacob, who, together with Yinan Liu, Douglas Robinson and team, found that the RNA-binding protein RNP1A regulates cell shape in Dictyostelium amoebas. In this snapshot, Mark takes us through the key findings from their research.
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Imaging spotlight - How to divide without a ring: a mechanical ratchet drives unilateral cytokinesis

Posted by , on 10 February 2026

In this paper highlight, Jan Brugués and Alison Kickuth discuss the microscopy and microrheology techniques that they used in their research dissecting the mechanics of cytokinesis.
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Workshop report: EMBO Course on Image Processing in Cryo-EM

Posted by , on 9 February 2026

Freya Cardozo shares her workshop report from the EMBO course on Imaging Processing in Cryo-EM. Freya's attendance was supported with a JCS-FocalPlane Training Grant.
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Imaging spotlight: ShapeSpaceExplorer

Posted by , on 5 February 2026

In this paper highlight, we learn about ShapeSpaceExplorer, a tool for measuring cell shape of migrating cells, developed by Samuel Jefferyes, Anne Straube and colleagues.
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Microscopy preprints – applications in biology

Posted by , on 23 January 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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