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Microscopy preprints – applications in biology

Posted by , on 23 January 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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Cytoneme Imaging Tips and Tricks

Posted by , on 19 January 2026

There has been a growing interest in visualizing long and thin membrane extensions. The field of intercellular connections has exploded, with elegant bioimaging studies focusing on structures like cytonemes, tunneling nanotubes (TNTs), intercellular/cytokinetic bridges (IB/CBs), and migrasomes. This enhanced interest in the intercellular communication facilitated by these extensions is largely due to the recent technological
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Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy

Posted by , on 16 January 2026

In this highlight, Kruno Vukušić and Iva M. Tolić describe how they use multi-scale live lattice light-sheet and super-resolution microscopy to decipher the earliest steps of chromosome congression.
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JCS snapshot: the endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology

Posted by , on 14 January 2026

In our latest JCS snapshot we hear from Sebabrata Maity, who, together with Oishee Chakrabarti and colleagues, discovered that the endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology.
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JCS snapshot - Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation

Posted by , on 12 January 2026

In our latest JCS snapshot we hear from Anne Müsch, who, together with David Cohen and Francisco Lázaro-Diéguez, discovered that bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organisation.
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Imaging spotlight: Lock-in-SIM

Posted by , on 8 January 2026

In this paper highlight from Wenjie Liu and colleagues, we learn about Lock-in-SIM, a new methodology for structured illumination microscopy.
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Damage done, tubules on - Studying membrane damaged-induced lysosomal tubulation 

Posted by , on 11 December 2025

In this post, I'll told you the "ins and outs" of our last publication in JCB about lysosomal tubulation in response to damage.
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Epithelial Mechanics Fan Club

Posted by , on 4 December 2025

In this post, Nimesh Chahare and Julia Eckert tell us about the 'Epithelial Mechanics Fan Club'. You can follow the club on Bluesky, X, and now on their new website. Reach out to Nimesh and Julia if you would like to contribute.
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JCS snapshots: the cilia and flagella edition

Posted by , on 24 November 2025

Journal of Cell Science recently published a Special Issue on Cilia and Flagella: from Basic Biology to Disease, edited by Pleasantine Mill and Lotte Pedersen. We invited the authors of the research published in this issue to produce JCS snapshots, short videos highlighting the key findings from their papers. Below, you can find the snapshots
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JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease'

Posted by , on 10 November 2025

We'll be celebrating the research published in JCS's special issue on cilia and flagella with the UK Cilia and Centrosome Network at their upcoming symposium on Tuesday 25 November.
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