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Imaging spotlight: Cryo-ExM reveals the architecture of the human cytotoxic immunological synapse

Posted by , on 15 June 2026

In this behind the paper story, Benita Wolf and colleagues share their research using cryo-expansion microscopy (cryo-ExM) to map the architecture of the human cytotoxic immunological synapse.
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Microscopy preprints: applications in biology

Posted by , on 29 May 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
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New webinar series on cell migration

Posted by , on 29 May 2026

We are excited to announce a new quarterly webinar series on cell migration. In our first webinar, we'll hear talks from Juan Manuel Garcia Arcos, Yohalie Kalukula and Daniel J. Cohen.
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Imaging spotlight: PLIN5 phosphorylation tunes mitochondria–lipid droplet coupling in the liver

Posted by , on 29 April 2026

In this paper highlight, we hear from Natalie Porat-Shliom, who discusses her recent paper on how PLIN5 phosphorylation regulates mitochondria–lipid droplet contacts in the liver.
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Imaging spotlight: Calibrating expansion microscopy to map receptor sorting domains in endosomes

Posted by , on 15 April 2026

In this behind the paper story, Tayla Shakespeare and Izzy Jayasinghe share their research mapping receptor sorting domains in endosomes using expansion microscopy (ExM). As part of this research, they developed a calibrated 3D ExM toolkit to measure local expansion.
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Featured image with Emily Oren

Posted by , on 10 April 2026

Our featured image, acquired by Emily Oren, shows the surface stiffness of an Arabidopsis thaliana hypocotyl. It was acquired using a Bruker Biowizard 5 Atomic Force Microscope (AFM) and is of plasmolysed epidermal cells on a live seedling.
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Imaging spotlight: dissecting the precancerous niche

Posted by , on 25 March 2026

In this paper highlight we hear from Greta Skrupskelyte and Maria Alcolea, who discuss their recent paper dissecting the role of the microenvironment and tumour-stromal communication in tumour growth and survival.
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Imaging spotlight: Altair-LSFM

Posted by , on 9 March 2026

In this paper highlight from Kevin Dean and colleagues, we learn about Altair-LSFM, a light-sheet fluorescence microscope that they designed so it can be built and operated in biology labs without needing a full-time optical engineer.
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Microscopy preprints - applications in biology

Posted by , on 9 March 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.
Read more

JCS snapshot: Redefining colocalization analysis with a novel phasor mixing coefficient

Posted by , on 6 March 2026

In our latest JCS snapshot we hear from Owen Puls, who together with Teng-Leong Chew and team define a new strategy for quantifying biological association that leverages multispectral imaging and phasor analysis, termed the phasor mixing coefficient (PMC). In this snapshot, Owen takes us through the key findings from their research.
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