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Featured image with Thibault Dhellemmes and Jérémie Teillon

Posted by , on 1 March 2024

Our featured image shows the full morphology of Relaxin-3 neurons in an entire adult mouse brain. To observe the full depth of this brain, it was made transparent by applying an optical clearing technique called Adipoclear. The sample was observed on an Ultramicroscope II light sheet microscope and is a maximum intensity projection over the
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Featured image with Virginia Barrera

Posted by , on 2 February 2024

Our featured image was acquired by Virginia Barrera and was the winning image from the Institute of Molecular and Cellular Biology of Rosario (IBR-CONICET) annual retreat. It depicts a transversal cut of a soybean, with Calcofluor White staining cellulose and Basic Fuchsine labelling lignin.
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Tissue clearing: what invisible samples reveal about biology

Posted by , on 8 September 2021

Written by Jorge Almagro and Hendrik Messal The tissues that constitute organs exist in our body in 3D. However, for practical reasons, histological analysis has been traditionally performed in 2D, slicing a few micrometer-thick sections to analyse them under the microscope. While this has been critical to understand our anatomy for centuries, it constitutes a simplification of
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