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See more with HCR spectral imaging

Posted by , on 6 March 2024

In a new paper published in Development, Samuel Schulte, Niles Pierce and colleagues present a new workflow for HCR spectral imaging with linear unmixing, for simultaneous imaging of ten RNA and/or protein targets in both whole-mount zebrafish embryos and mouse brain sections.
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Featured image with Thibault Dhellemmes and Jérémie Teillon

Posted by , on 1 March 2024

Our featured image shows the full morphology of Relaxin-3 neurons in an entire adult mouse brain. To observe the full depth of this brain, it was made transparent by applying an optical clearing technique called Adipoclear. The sample was observed on an Ultramicroscope II light sheet microscope and is a maximum intensity projection over the
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New FocalPlane features... webinar series

Posted by , on 22 February 2024

We are excited to announce a new series of FocalPlane features… webinars. Our first webinar, on 7 March at 15:00 GMT (10:00 PET) focusses on outreach projects using microscopy, with talks from Paola Moreno-Roman, Alexander Strachan and Martin Jones.
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Featured image with Rossana Melo

Posted by , on 16 February 2024

Our featured image, acquired by Rossana Melo, shows a human eosinophil isolated from the peripheral blood using a negative immunomagnetic selection method and prepared for transmission electron microscopy (TEM). The image was acquired with a Tecnai G2 Spirit Bio Twin ThermoFisher Scientific (former FEI) electron microscope.
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Featured image with Virginia Barrera

Posted by , on 2 February 2024

Our featured image was acquired by Virginia Barrera and was the winning image from the Institute of Molecular and Cellular Biology of Rosario (IBR-CONICET) annual retreat. It depicts a transversal cut of a soybean, with Calcofluor White staining cellulose and Basic Fuchsine labelling lignin.
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Announcing the 2024 FocalPlane correspondents

Posted by , on 1 February 2024

We are delighted to announce that we are continuing our FocalPlane correspondent programme and in 2024 we will be working with Daniel Doucet, Subhajit Dutta and Greg Redpath. They will benefit from a programme of writing groups, webinars and workshops coordinated by the in-house team at The Company of Biologists and will produce approximately six
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Time-resolved confocal fluorescence microscopy from PicoQuant

Sponsored by PicoQuant, on 31 January 2024

On January 11th Professor Samrat Mukhopadhyay shared insights into the complicated behavior of the FUS low-complexity domain during liquid-liquid phase separation. He and his team study protein dynamics at the single molecule level with Fluorescence Correlation Spectroscopy (FCS), single-molecule FRET (smFRET), and anisotropy to gain a comprehensive understanding. His excellent presentation sparked great interest: All
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FocalPlane features... Samrat Mukhopadhyay with PicoQuant

Posted by , on 31 January 2024

In case you missed ‘FocalPlane features…’, here is the recording of the webinar given by Samrat Mukhopadhyay on 'A deep dive into biomolecular condensates using single-molecule FRET', which we co-hosted with PicoQuant.
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New Reviews Editor at Journal of Cell Science

Posted by , on 25 January 2024

Dear FocalPlane community, Hi all, my name is Sara Morais da Silva and I recently joined the Company of Biologists as a Reviews Editor for the Journal of Cell Science.  In my new role, I will be working together with the JCS team, to publish review-type articles, Research Highlights and Cell Science at a glance
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Invitation to follow the LCI microscopy course on Zoom

Posted by , on 24 January 2024

It is my pleasure to invite you to follow the LCI facility microscopy course Microscopy: improve your imaging skills – from sample preparation to image analysis. The course starts next Monday (29 Jan) and runs until the 16th of February.As usual, all the course lectures are broadcasted live on Zoom. It is free of charge
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