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Seeing comes before knowing: how live imaging led to the discovery of blood vessel-resident macrophages

Posted by FocalPlane, on 12 August 2026

Bart Weijts and Catherine Robin share the behind the paper story on their discovery of blood vessel-resident macrophages.

JCS snapshot - Live imaging of epithelial phagocyte differentiation in the Drosophila ovary reveals transient and novel behaviours

Posted by FocalPlane, on 11 August 2026

In our latest JCS snapshot we hear from Caique Almeida Machado Costa, who, together with Wu-Min Deng and team, used time-lapse imaging to uncover dynamic behaviours during epithelial-to-phagocyte differentiation, including migration, delamination, long-range target capture and cell engulfment. In this snapshot, Cai take us through the key findings from their research.

Imaging spotlight: FidlTrack

Posted by FocalPlane, on 10 August 2026

In this Imaging spotlight, we hear from Pierre Parutto and Edward Avezov about FidlTrack, a method for benchmarking and optimising single particle tracking.

Microscopy preprints – new tools and techniques in imaging

Posted by FocalPlane, on 7 August 2026

Here is a curated selection of the latest preprints on new tools and techniques in imaging. Let us know if we are missing any recent preprints that are on your reading list!

Imaging spotlight: fluorogenic L-DNA probes

Posted by FocalPlane, on 6 August 2026

In this Imaging spotlight, we hear from Bas van Bommel and Helge Ewers about the fluorogenic L-DNA probes they used to optimise DNA-PAINT labelling for single molecule localisation microscopy.

FocalPlane features… Laura Bacete and Sven Truckenbrodt

Posted by FocalPlane, on 5 August 2026

View the recordings from our second webinar on quantitative plant imaging. We heard from Laura Bacete, on ‘Brillouin Microscopy for Quantitative Analysis of Plant Cell Wall Mechanics Across Systems’ and Sven Truckenbrodt on ‘PlantEx: multicolour super-resolution imaging of plants with expansion microscopy’.

Featured image with Saheli Roy

Posted by FocalPlane, on 3 August 2026

Our featured image, acquired by Saheli Roy, depicts a maximum intensity projection of a female Drosophila melanogaster‘s reproductive system – both ovaries, lateral and common oviducts, uterus and seminal receptacle (an organ for sperm storage that allows the female fly to control fertilization). The ovaries are full of auto-fluorescent developing and mature eggs, because the

Microscopy preprints: bioimage analysis

Posted by FocalPlane, on 24 July 2026

Here is a curated selection of preprints published or updated recently. In this post we focus specifically on bioimage analysis and data management.

JCS snapshot: A ULK1–MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis

Posted by FocalPlane, on 22 July 2026

In our latest JCS snapshot we hear from Riccardo Babic, Leon Lucya and Christoph Reiter, who, together with Claudine Kraft and team, identified a ULK1–MTFR1L feedback loop that links mitochondrial fission, mitophagy and apoptosis.

Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture

Posted by FocalPlane, on 21 July 2026

In this highlight, we hear from Juan C. Landoni, who discusses his recent work uncovering how mitochondria distribute their genome through pearling (Landoni et al. 2026, Science), and the key role of mitochondrial trafficking in maintaining new material dissemination and network architecture (Winter, Landoni et al. 2026, JCB).

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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