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Upcoming webinar: A deep dive into biomolecular condensates using single-molecule FRET

Posted by , on 11 December 2023

We are delighted to open the registration for our FocalPlane features… webinar with Samrat Mukhopadhyay. The webinar, co-hosted with PicoQuant, will take place on Zoom on Thursday 11 January at 14:00 GMT (15:00 CET and 19:30 IST). Samrat will talk about recent research from his group at IISER Mohali describing the use of single-molecule FRET to study liquid-like biomolecular condensates, followed by a Q&A session. The webinar will be recorded.

By registering to attend the webinar, you agree to abide by the Code of Conduct.

Registration will close 30mins before the start of the webinar.

Abstract: Cells contain membrane-enclosed organelles that compartmentalize cellular constituents and regulate biochemistry. A growing body of fascinating research now reveals that there is also an alternative mechanism of spatiotemporally-controlled intracellular compartmentalization and organization via liquid-liquid phase separation of proteins and nucleic acids into noncanonical membrane-less organelles. These functional liquid-like biomolecular condensates can undergo aberrant irreversible phase transitions into gel-like or solid-like amyloid aggregates associated with a range of debilitating human diseases. In this talk, I will describe that single-molecule FRET studies offer an incredibly powerful approach to illuminating the exquisite inner workings of phase-separated biomolecular condensates. These studies allow us to dissect the coexisting conformational states and unmask the crucial molecular events that are otherwise skewed in conventional ensemble-averaged experiments. Our findings provide broad mechanistic underpinnings involving an intriguing interplay of sequence-encoded dynamically-controlled making and breaking of weak interactions that govern biological phase transitions involved in cell physiology and disease.

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