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New Intern for FocalPlane

Posted by , on 14 August 2024

Hi everyone!

My name is Ryan Harrison and I’m an intern who will be working on the community sites at The Company of Biologists, including FocalPlane, for the next three months.

The first time I was properly introduced to microscopy was during my Master’s (MSci) project in Lancaster University. My project was between the labs of Morgan Gadd and Andrew Fielding, working with Amanda Thomaz, where I was investigating supernumerary centrosomes in difficult-to-treat breast cancers. Here, I was able to take fantastic fluorescence images, and I decided to pursue a PhD that would allow me to carry on using fluorescence microscopy.

Fluorescence image showing a breast cancer cell undergoing a multipolar mitosis, where there are too many centrosomes (red) in the cell, and the spindle (grey) is pulling the DNA (blue) in too many directions. This means the cell won’t be able to divide properly and will die.

Following my undergraduate studies, I joined the MRC DTP in Interdisciplinary Biomedical Research at the University of Warwick, where I am currently pursuing a PhD between the labs of Timothy Saunders and James Briscoe (Francis Crick Institute) researching organoids mimicking embryonic development of the lower back and spine. There is still a large microscopy component to my research, and I really enjoy using the lab’s spinning disc confocal microscope.

Fluorescence images of some organoids I have grown in the lab. In the organoid on the left, we can see how different cell fates emerge (red and yellow), and on the right we can see the some of the cellular cytoarchitecture (green) in the organoid.

I’m looking forward to getting to know the microscopy community here at FocalPlane and seeing all the cool microscopy images as well! Feel free to contact me at focalplane@biologists.com or ryan.harrison@biologists.com.

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