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Probes 101 – How to choose a fluorescent probe for your imaging experiment

Posted by Lina El Hajji, on 14 December 2024

Fluorescence microscopy is a powerful tool for the visualization of the intricate biological processes occurring within biological organisms. Just like you can make important pieces of information pop up in their notes using colorful highlighters, biologists have at hand a large toolkit of “highlighters” to make their favorite targets stand out in the complex cellular

FocalPlane features... Imaging Cell Architecture and Dynamics with Journal of Cell Science

Posted by FocalPlane, on 15 November 2024

Our latest FocalPlane features… webinar was a celebration of the research in Journal of Cell Science’s Special Issue: Imaging Cell Architecture and Dynamics. Our Guest Editors Lucy Collinson and Guillaume Jacquemet hosted the webinar with talks from Md Hashim Reza, Melanie Rug and Vikas Tillu.

Advantages of LED Illumination for Neuroscience Research

Sponsored by CoolLED, on 26 September 2024

LED microscopy illumination has disrupted traditional approaches to high-speed imaging and optogenetic stimulation for neuroscience, and the CoolLED Support Team are available to help researchers understand which filters, light sources and other components are right for each individual setup.

Structural Repetition Detector (SReD): quantitative mapping of molecular complexes through microscopy

Posted by Afonso Mendes, on 23 September 2024

Unbiased, multi-dimensional, multi-scale and GPU-accelerated analysis of structural patterns across all microscopy modalities From biomolecules to larger assemblies and cellular architectures, molecular structures govern biological processes. Identifying these repetitive patterns is essential to understand their functions and the underlying biological mechanisms. While microscopy offers molecular-level detail, manually detecting structural motifs is labor-intensive, susceptible to bias,

FocalPlane features... data management

Posted by FocalPlane, on 23 September 2024

The fourth webinar in the latest series of FocalPlane features… was on data management. Caterina Strambio De Castillia introduced us to the topic of research data management, while Tom discussed how to use OMERO from the perspective of a group leader, a microscopist and an image analyst. We wrapped up the webinar with a short

MicroList and FocalPlane join forces

Posted by FocalPlane, on 2 September 2024

MicroList’s database of resources are now available on FocalPlane. The resources, which have been created by the global imaging community, are presented as cards that are divided into community resources, education resources and tools. The database is fully searchable using our search bar or can be filtered using a variety of categories.

BioImage.IO Chatbot: Ready to use and discover!

Posted by Caterina Fuster-Barceló, on 21 August 2024

We are delighted to announce the publication of the BioImage.IO Chatbot in Nature Methods this August and its immediate availability for the bioimaging community. This milestone signifies academic recognition and marks the chatbot’s readiness for everyday use in streamlining complex bioimage analysis tasks. Broadening Access to Advanced Bioimage Analysis The BioImage.IO Chatbot, equipped with state-of-the-art

DL4MicEverywhere - Overcoming reproducibility challenges in deep learning microscopy imaging

Posted by Iván Hidalgo-Cenalmor, on 29 July 2024

DL4MicEverywhere is out! Learn about it and how you can apply deep learning workflows on microscopy imaging in reproducible research and in a user-friendly manner across different systems.

A general strategy to develop fluorogenic polymethine dyes for bioimaging

Posted by Annabell Martin, on 6 December 2023

by Annabell Martin and Pablo Rivera-Fuentes. Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development of novel advanced fluorescent probes. Excitingly, using polymethines as a scaffold for fluorogenic dyes, we have opened up a lot of new avenues for bioimaging.

Working smarter with LEDs and optical filters for widefield fluorescence

Sponsored by CoolLED, on 13 September 2023

Optical filters can make or break a fluorescence microscopy experiment. For widefield fluorescence, they also have the potential to unlock breakthroughs in high-speed, high-contrast imaging when used alongside multi-channel LED illumination systems. There are thousands of filters and dichroic mirrors to choose from, with the selection depending on the fluorophore(s) and light source. While imaging

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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