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Overview of Microscopy Techniques: Confocal, Widefield, Transmitted Light and Deconvolution

Sponsored by Andor, on 30 November 2021

Microscopes are an essential tool for modern life science applications. From medical diagnostics (for example, identifying the source of an infection, or the severity of a tumour) to food analysis.  With such demand it is not surprising that in the last decade, there has been a boom in microscopy technologies allowing researchers to see beyond
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Primed conversion: the Basics

Posted by , on 15 November 2021

It has been a bit more than 6 years since the first “primed conversion” article1 was published in May 2015 and around 3 years since I first heard about this new photoconversion technique. I recall that it was almost 1 year after I got my MSc in Greece when I contacted Dr Periklis (Laki) Pantazis
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Meet BC43, Andor’s New Benchtop Confocal Microscope

Sponsored by Andor, on 8 November 2021

Andor Technology, an Oxford Instruments company and world leader in scientific imaging solutions, today announced the addition of BC43, a revolutionary benchtop confocal system, to its award-winning microscopy portfolio.  A Big Deal in a Small Box An affordable and high-speed confocal microscope, with a small footprint, BC43 is purposefully easy to use, allowing researchers to
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PUMA Open Source Multimodality 3D Printed Microscope

Posted by , on 26 October 2021

PUMA is an advanced direct vision 3D printed multimodality microscopy system with fluorescence ,phase contrast, Köhler illumination and augmented reality functions - and more.
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Temperature control in light microscopy – challenges and solutions

Sponsored by Interherence, on 9 September 2021

We describe common challenges that researchers face when trying to precisely control the temperature of the sample they are imaging. We aim to show that thermal control in high sensitivity microscopy is not trivial if you care about temperature directly in the field of view of the microscope (which you should). We hope to persuade
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Tissue clearing: what invisible samples reveal about biology

Posted by , on 8 September 2021

Written by Jorge Almagro and Hendrik Messal The tissues that constitute organs exist in our body in 3D. However, for practical reasons, histological analysis has been traditionally performed in 2D, slicing a few micrometer-thick sections to analyse them under the microscope. While this has been critical to understand our anatomy for centuries, it constitutes a simplification of
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Dragonfly: The Ideal Confocal System for Expansion Microscopy

Sponsored by Andor, on 30 August 2021

Challenges in Imaging Expanded Samples The resolution in light microscopy is limited by the diffraction limit of light, which means that structures that are closer than 200 nm apart cannot be distinguished unless researchers use Super-resolution techniques. An alternative approach to super-resolution methods was developed by Edward Boyden’s laboratory at MIT in 2015 [1]. Instead of increasing
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Turn Your Inverted Microscope into a Multimodal Nanoscope

Sponsored by Olympus, on 14 June 2021

Among recent nanoscopy techniques that break the diffraction limit, single-molecule localization microscopy (SMLM) contributes to major discoveries in medicine and biology. It is now possible to see how subcellular molecular machineries form and behave inside single cells and to quantify single biological molecules such as proteins, nucleic acids, and lipids, at ultralow concentrations inside the
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What is Expansion Microscopy?

Sponsored by Andor, on 27 May 2021

How can you get the most information from expanded samples? Traditional light microscopy is limited by the diffraction of light, consequently, features less than 200 nm apart cannot be resolved. For a significant time microscopy technique development was focused towards improving imaging techniques to allow for individual molecules to be resolved. Super-resolution microscopy was developed
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Compact and High Performance Fluorescence Microscopy

Sponsored by Etaluma, on 28 April 2021

“Disruptive technologies typically enable new markets to emerge… disruptive products are simpler and cheaper;” Clayton M. Christensen, The Innovator’s Dilemma Microscopes are the most common laboratory instrument in the world; there are more labs with a microscope in them than any other instrument.  As such, it is a field where innovation is constantly producing new
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