vEM - FocalPlane

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Microscopy preprints - applications in biology

Posted by FocalPlane, on 21 February 2025

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.

Kidney elastic fiber network changes in Marfan's Syndrome

Posted by Mario Elias Ortega Sandoval, on 19 July 2024

by de Souza RB*, Meek KM#, Lewis PN#, Pereira LV*. *Department of Genetics and Evolutionary Biology, University of São Paulo, Brazil #StructuralbBiophysics Research Group, School of Optometry and Vision Sciences of the United Kingdom, Cardiff University, UK Challenge Marfan’s syndrome (MFS) is an autosomal dominant disorder that affects the connective tissue, resulting from a mutation

Targeted vCLEM of heterogeneous samples

Posted by Mario Elias Ortega Sandoval, on 15 January 2024

by Karel Mocaer* and Paolo Ronchi# *Schwab Team and #EMCF, EMBL Heidelberg, Germany Challenge Studying cells or events within their biological context (i.e. in tissues, ecosystem etc…) is highly relevant. However, volume EM techniques are limited in the volume that can be acquired. Therefore, targeting approaches are needed to characterize specific regions of interest. This

Deciphering cardiac multiscale organization

Posted by Georgina Fletcher, on 11 December 2023

by Sandra Rugonyi and Claudia López Oregon Health & Science University, Portland Oregon, USA Challenge The morphology, microstructure, and ultrastructure of heart tissues is exquisitely organized to optimize cardiac efficiency. In cases of cardiac malformations, known as congenital heart disease (CHD), spatially heterogeneous and abnormal ultrastructural patterns emerge as early as fetal stages that worsen

Insights into the leaky Blood Brain Barrier by vEM

Posted by Georgina Fletcher, on 4 August 2023

by Martina Schifferer, German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology SyNergy, Germany DOI: 10.1242/focalplane.15936 Challenge The Blood Brain Barrier (BBB) controls the exchange between blood and the brain parenchyme. Its structural determinants comprise tight junctions and endothelial vesicles which require resolution at the nanometer scale. In disease like stroke or traumatic brain

FocalPlane features... CLEM

Posted by FocalPlane, on 31 January 2022

In case you missed ‘FocalPlane features…’ this month, here is the recording of the webinar given by Yannick Schwab (EMBL Heidelberg), Ori Avinoam (Weizmann Institute of Science) and Alexandra Pacureanu (ESRF The European Synchrotron) on Monday 17 January 2022.

FocalPlane features... Data Analysis for volume EM

Posted by FocalPlane, on 16 November 2021

In case you missed ‘FocalPlane features…’ this month, here is the recording of the webinar given by Anna Kreshuk (EMBL Heidelberg), Dagmar Kainmueller (MDC Berlin) and Jan Funke (Janelia Research Campus) on Monday 8 November 2021.

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Microscopy-related articles from our journals

HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples Development 2024 151: dev202307
filoVision – using deep learning and tip markers to automate filopodia analysis J Cell Sci 2024 137: jcs261274
C omputational tools for quantifying actin filament numbers, lengths, and bundling Biology Open 2024 13: bio.060267

Microscopy-related preprint highlights

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