Light-sheet microscopy

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Microscopy preprints – applications in biology

Posted by FocalPlane, on 23 January 2026

Here is a curated selection of preprints published recently. In this post, we share preprints that use microscopy tools to answer questions in biology.

Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy

Posted by Kruno Vukušić, on 16 January 2026

In this highlight, Kruno Vukušić and Iva M. Tolić describe how they use multi-scale live lattice light-sheet and super-resolution microscopy to decipher the earliest steps of chromosome congression.

Vote for your favourite 'Featured image' from 2025

Posted by FocalPlane, on 19 December 2025

Throughout 2025, we highlighted some fantastic images and researchers in our 'Featured image' series. Here is your chance to vote for your favourite.

Imaging spotlight: u-Segment3D

Posted by FocalPlane, on 11 December 2025

In this paper highlight, we learn about u-Segment3D, a software framework developed by Felix Zhou and Gaudenz Danuser and colleagues.

Workshop report: France BioImaging - Advanced Training on Light-Sheet Microscopy

Posted by Clara Hayn, on 22 May 2025

From November 4th to 7th, 2024, I had the privilege to attend the Advanced Training on Light-Sheet Microscopy‘s Principles and Applications to Neuroscience and 3D Cell Culture at France BioImaging in Bordeaux. This comprehensive training, rich in both theoretical and practical knowledge, provided an exceptional platform for learning and engaging with experts in the field.

Enhancing Global Access: interview with CZI grantee Alenka Lovy

Posted by Mariana De Niz, on 24 January 2024

DEVELOPING A LATIN AMERICAN LIGHT-SHEET BIOIMAGING HUB Alenka Lovy is a principal investigator at Universidad Mayor in Chile. She is also the leader of LiSIUM (the Light Sheet Imaging Unit at Universidad Mayor). Her CZI project aims to connect multiple labs in the region, including institutions in Chile, Brazil, and Uruguay, to implement light sheet

Enhancing Global Access: interview with CZI grantee Michael Weber

Posted by Mariana De Niz, on 24 January 2024

UNLOCKING NEW BIOLOGICAL RESEARCH WITH MODULAR AND SHAREABLE ‘FLAMINGO’ LIGHT SHEET MICROSCOPES Michael Weber has focused a lot of his career in microscopy development. He is a grantee of the CZI cycle 1 grants to imaging scientists. As part of his project, he helps developing light sheet microscopes called ‘Flamingos’ that can travel between research

An interview with Alenka Lovy

Posted by Mariana De Niz, on 27 November 2022

MiniBio: Dr. Alenka Lovy is an Assistant Professor at the Center for Integrative Biology (CIB) and in charge of LiSIUM, LightSheet Imaging at Universidad Mayor. where together with a team of researchers, she is introducing this novel platform to the Latin American region. Alenka is originally from the Czech Republic. She did her early studies

An interview with Ramón Ramírez

Posted by Mariana De Niz, on 8 November 2022

MiniBio: Dr. Ramon Ramirez is the Coordinator of the Microscopy Centre at Universidad Mayor in Santiago de Chile, and a leading member at LiSIUM (the light sheet imaging centre). He did his early career in Chile, at Pontificia Universidad Católica de Valparaíso where he studied a BSc in Biology. He later went to Madrid to

Tissue clearing: what invisible samples reveal about biology

Posted by jorgealmagr, on 8 September 2021

Written by Jorge Almagro and Hendrik Messal The tissues that constitute organs exist in our body in 3D. However, for practical reasons, histological analysis has been traditionally performed in 2D, slicing a few micrometer-thick sections to analyse them under the microscope. While this has been critical to understand our anatomy for centuries, it constitutes a simplification of

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Microscopy-related articles from our journals

Toggle-Untoggle – a cell segmentation tool with an interactive user verification interface J Cell Sci 2025 138: jcs264154
The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential Development 2025 152: dev204661
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity Biology Open 2025 14: bio062117

Microscopy-related preprint highlights

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Microscopy-related articles from our journals

Microscopy-related preprint highlights

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